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May 5

Beyond Pixel Simulation: Pathology Image Generation via Diagnostic Semantic Tokens and Prototype Control

In computational pathology, understanding and generation have evolved along disparate paths: advanced understanding models already exhibit diagnostic-level competence, whereas generative models largely simulate pixels. Progress remains hindered by three coupled factors: the scarcity of large, high-quality image-text corpora; the lack of precise, fine-grained semantic control, which forces reliance on non-semantic cues; and terminological heterogeneity, where diverse phrasings for the same diagnostic concept impede reliable text conditioning. We introduce UniPath, a semantics-driven pathology image generation framework that leverages mature diagnostic understanding to enable controllable generation. UniPath implements Multi-Stream Control: a Raw-Text stream; a High-Level Semantics stream that uses learnable queries to a frozen pathology MLLM to distill paraphrase-robust Diagnostic Semantic Tokens and to expand prompts into diagnosis-aware attribute bundles; and a Prototype stream that affords component-level morphological control via a prototype bank. On the data front, we curate a 2.65M image-text corpus and a finely annotated, high-quality 68K subset to alleviate data scarcity. For a comprehensive assessment, we establish a four-tier evaluation hierarchy tailored to pathology. Extensive experiments demonstrate UniPath's SOTA performance, including a Patho-FID of 80.9 (51% better than the second-best) and fine-grained semantic control achieving 98.7% of the real-image. The meticulously curated datasets, complete source code, and pre-trained model weights developed in this study will be made openly accessible to the public.

  • 8 authors
·
Dec 24, 2025

UncTrack: Reliable Visual Object Tracking with Uncertainty-Aware Prototype Memory Network

Transformer-based trackers have achieved promising success and become the dominant tracking paradigm due to their accuracy and efficiency. Despite the substantial progress, most of the existing approaches tackle object tracking as a deterministic coordinate regression problem, while the target localization uncertainty has been greatly overlooked, which hampers trackers' ability to maintain reliable target state prediction in challenging scenarios. To address this issue, we propose UncTrack, a novel uncertainty-aware transformer tracker that predicts the target localization uncertainty and incorporates this uncertainty information for accurate target state inference. Specifically, UncTrack utilizes a transformer encoder to perform feature interaction between template and search images. The output features are passed into an uncertainty-aware localization decoder (ULD) to coarsely predict the corner-based localization and the corresponding localization uncertainty. Then the localization uncertainty is sent into a prototype memory network (PMN) to excavate valuable historical information to identify whether the target state prediction is reliable or not. To enhance the template representation, the samples with high confidence are fed back into the prototype memory bank for memory updating, making the tracker more robust to challenging appearance variations. Extensive experiments demonstrate that our method outperforms other state-of-the-art methods. Our code is available at https://github.com/ManOfStory/UncTrack.

  • 5 authors
·
Mar 17, 2025

Dia-LLaMA: Towards Large Language Model-driven CT Report Generation

Medical report generation has achieved remarkable advancements yet has still been faced with several challenges. First, the inherent imbalance in the distribution of normal and abnormal cases may lead models to exhibit a biased focus on normal samples, resulting in unreliable diagnoses. Second, the frequent occurrence of common template sentences in the reports may overwhelm the critical abnormal information. Moreover, existing works focus on 2D chest X-rays, leaving CT report generation underexplored due to the high-dimensional nature of CT images and the limited availability of CT-report pairs. Recently, LLM has shown a great ability to generate reliable answers with appropriate prompts, which shed light on addressing the aforementioned challenges. In this paper, we propose Dia-LLaMA, a framework to adapt the LLaMA2-7B for CT report generation by incorporating diagnostic information as guidance prompts. Considering the high dimension of CT, we leverage a pre-trained ViT3D with perceiver to extract the visual information. To tailor the LLM for report generation and emphasize abnormality, we extract additional diagnostic information by referring to a disease prototype memory bank, which is updated during training to capture common disease representations. Furthermore, we introduce disease-aware attention to enable the model to adjust attention for different diseases. Experiments on the chest CT dataset demonstrated that our proposed method outperformed previous methods and achieved state-of-the-art on both clinical efficacy performance and natural language generation metrics. The code will be made publically available.

  • 4 authors
·
Mar 24, 2024